Boosting one protein helps the brain fight Alzheimer’s

Researchers at Baylor College of Medicine have uncovered a built in process that can remove existing amyloid plaques from the brains of mouse models of Alzheimer's disease while also helping preserve memory and thinking ability. The discovery centers on astrocytes, star shaped support cells in the brain, which can be directed to clear away the toxic plaque deposits commonly seen in Alzheimer's.

The team found that increasing levels of Sox9, a protein that plays a major role in regulating astrocyte activity during aging, significantly improved these cells' ability to remove amyloid plaques. The findings, published in Nature Neuroscience, point to a potential treatment strategy that focuses on boosting the brain's own support system to slow cognitive decline in neurodegenerative disease.

"Astrocytes perform diverse tasks that are essential for normal brain function, including facilitating brain communications and memory storage. As the brain ages, astrocytes show profound functional alterations; however, the role these alterations play in aging and neurodegeneration is not yet understood," said first author Dr. Dong-Joo Choi, who conducted the work while at Baylor's Center for Cell and Gene Therapy and Department of Neurosurgery. Choi is now an assistant professor at the Center for Neuroimmunology and Glial Biology, Institute of Molecular Medicine at the University of Texas Health Science Center at Houston.