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Mayim Bialik's GLP-1 Experience Left Her With ‘Uncontrollable’ GI Symptoms
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Mayim Bialik's GLP-1 Experience Left Her With ‘Uncontrollable’ GI Symptoms

Healthline · Jun 17, 2026, 5:00 PM · Also reported by 1 other source

Why this matters: health reporting relevant to everyday decisions and well-being.

Mayim Bialik recently shared the “nightmare” experience she had after using a GLP-1 drug. Image Credit: Laurent Koffel/Getty Images Actor Mayim Bialik has shared her “nightmare” experience that left her with weeks of side effects after one GLP-1 medication dose. Bialik said her symptoms included severe diarrhea and full-body aches. She revealed that she tried a GLP-1 after her doctor suggested it may help with her autoimmune disease symptoms. Emmy Award-winning actor Mayim Bialik, of “Blossom” and “Big Bang Theory” fame, opened up about her experience with a GLP-1 medication. In an essay for The Free Press, Bialik wrote, “To say I had an adverse reaction would be somewhat of an understatement.” After one low dose injection of the GLP-1 medication, she said she began to experience gastrointestinal symptoms that left her unwell for weeks. When Bialik visited a gastroenterologist about her symptoms, she was told that dramatic side effects from GLP-1 drugs can be quite common. The doctor also informed Bialik that the other medications she was taking may have contributed to her symptoms. Here’s why Bialik turned to GLP-1s and why her autoimmune disease symptoms may have exacerbated her side effects. Bialik’s GLP-1 experience was a ‘nightmare’ Bialik shared that she had gained around 20 pounds during early menopause. However, that wasn’t why she started using a GLP-1 medication. She had been told that the medication may help ease some of the symptoms she had lived with most of her adult life. She was diagnosed with Graves’ disease, an autoimmune condition, when she was 23. At 48, Bialik consulted with various specialists for other symptoms she was experiencing after perimenopause. Each physician gave her a separate autoimmune diagnosis, but none seemed 100% certain. She decided to try a GLP-1, not for her postmenopause weight gain, but because three separate doctors suggested she try it to help with her autoimmune symptoms. There

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