Imperagen raises £5 million to use quantum physics, AI on enzyme engineering

Biotech company Imperagen announced on Thursday a £5 million ($6.7 million) seed round led by PXN Ventures, with participation from IQ Capital and Northern Gritstone. The company was founded in 2021 by Manchester Institute of Biotechnology scientists Dr. Andrew Currin, Dr. Tim Eyes, and Dr. Andy Almond and spun out of the university.

The startup seeks to improve enzyme engineering by making it faster, more efficient, and less costly than the slower, more physical, trial-and-error-focused process used now.

Imperagen is using three core technologies as it seeks to redefine enzyme engineering. Specifically, it uses a quantum physics-based simulation instead of trial-and-error enzyme mutations in a lab. Imperagen predicts the behavior of enzyme variants on a computer using advanced quantum physics modeling that can explore millions of mutations, the company said. Then it translates this information into its custom AI models, trained on the enzyme problems Imperagen seeks to explore. Finally, to retain its AI models, Imperagen uses robots and automation to generate experimental data, which is fed back to the AI model, in a process called closed-loop simulation.