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Oral GLP-1 pill delivers nearly 12 percent weight loss in 36 weeks, study finds
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Oral GLP-1 pill delivers nearly 12 percent weight loss in 36 weeks, study finds

The Hill · Jun 28, 2026, 12:16 PM · Also reported by 2 other sources

Key takeaways

  • The study, conducted at Northwestern University, found the drug stimulates insulin secretion, suppresses appetite and increases satiety to promote weight loss.
  • The difference with aleniglipron is it s a small molecule, meaning it s chemically made and can be taken with or without food, said Dr.
  • Researchers analyzed 230 adults with overweight or obesity across 38 U.S. medical centers.

Why this matters: political developments that affect policy direction and public trust.

The study, conducted at Northwestern University, found the drug stimulates insulin secretion, suppresses appetite and increases satiety to promote weight loss.

The difference with aleniglipron is it s a small molecule, meaning it s chemically made and can be taken with or without food, said Dr. Robert Kushner, a co-author of the study and a professor at Northwestern. Most medications we take — whether aspirin or blood pressure drugs — are small molecules. Because of that, they can potentially be combined with other medications.

Researchers analyzed 230 adults with overweight or obesity across 38 U.S. medical centers. Participants took once-daily oral doses of aleniglipron, with doses increasing every four weeks, or received a placebo over 36 weeks.

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