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STAT+: Definium LSD therapy helped patients with major depression in late-stage trial
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STAT+: Definium LSD therapy helped patients with major depression in late-stage trial

STAT News · Jun 22, 2026, 11:00 AM · Also reported by 1 other source

Why this matters: health reporting relevant to everyday decisions and well-being.

Definium Therapeutics said Monday that its LSD therapy significantly helped patients with major depression in its first Phase 3 trial, bringing the psychedelic drug closer to a potential approval. Six weeks after a single dose, patients on the pill, called DT120, experienced a 13.3-point drop on a depression test called the Montgomery-&#x C5;sberg Depression Rating Scale (MADRS), compared with a 5.2-point drop among patients taking placebo. By 12 weeks, the effect waned a bit but was largely maintained, as patients on the pill had an 11-point drop from their baseline, compared with a 3.6-point drop in the placebo group.Continue to STAT+ to read the full story…

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