Creatine Supplements May Help Treat Depression, Early Evidence Shows

A large review suggests that creatine could help treat major depressive disorder (MDD), but evidence is mixed. ATHVisions/Getty Images. A large review suggests that creatine could be an adjunct treatment for major depressive disorder (MDD). However, not all studies in the review found the same benefits for treating depression symptoms with creatine. Those with depression who would like to try creatine should continue with existing treatments, using it only as an add-on. Experts note that creatine supplements have an excellent safety profile when taken as directed. Lifestyle choices such as good sleep, exercise, nutrition, and stress management can also protect brain health. Creatine monohydrate, a popular dietary supplement commonly used by athletes and fitness enthusiasts to build muscle, could serve as an adjunct treatment for depression. A large systematic review explored the potential benefits of creatine for mental health. Researchers from the University of Ottawa and the University of Toronto analyzed randomized controlled trials (RCTs) conducted worldwide and found that creatine supplementation shows promise for improving symptoms of major depressive disorder (MDD). Their findings, however, are mixed, highlighting the need for further large-scale studies. The results were published in Brain Medicine on June 30. Depression affects around 332 million people worldwide, according to the World Health Organization (WHO). As the review authors highlight, many people experience only partial or no response to depression medications, making it essential to explore other treatment options. The authors say that creatine, known for its role in cellular energy metabolism, may help by providing an energy buffer for brain cells. This is particularly relevant, they add, because impaired energy metabolism and mitochondrial dysfunction have been linked to depression. Evidence for creatine as depression treatment The researchers examined the effects of creatine monohydrate supple